Cell cycle regulators kick out centrosomes
نویسندگان
چکیده
منابع مشابه
SnapShot: Cell-Cycle Regulators I
function Phase S. cerevisiae (Budding Yeast) S. pombe (fission Yeast) D. melanogaster (fruit fly)
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function S. cerevisiae (Budding Yeast) S. pombe (fission Yeast) D. melanogaster (fruit fly) X. laevis (clawed Toad) H. sapiens (Human) Cdk-inhibitory kinases Phosphorylate Cdk in active site, blocking activity swe1 Wee1, Mik1 Dwee1, Dmyt1 Wee1, Myt1 Wee1, Myt1 Cdk-activating phosphatases Dephosphorylate inhibitory phosphorylation of Cdk subunit
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Abstract Background: Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1). HTLV-1 oncogenes can induce malignancy through controlled gene expression of cell cycle checkpoints in the host cell. HTLV-I genes play a pivotal role in overriding cell cycle checkpoints and deregulate cellular division. In this study, we aimed to determine and comp...
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Most tumor suppressor genes (whose function in cancer biology was surmised by their inactivation or deletion) turn out to be important in normal cell growth and proliferation. Inactivation of these genes opens the gates to malignant transformation driven by aberrant growth signals. In general, tumor suppressor dysfunction does not initiate genomic instability or aneuploidy, hallmarks of the ori...
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Hematologic malignancies represent the fourth most frequently diagnosed cancer in economically developed countries. In hematologic malignancies normal hematopoiesis is interrupted by uncontrolled growth of a genetically altered stem or progenitor cell (HSPC) that maintains its ability of self-renewal. Cyclin-dependent kinases (CDKs) not only regulate the mammalian cell cycle, but also influence...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1746iti4